Sam Burgess will make his England debut at centre when Stuart Lancaster’s side host France on Saturday.
The former Great Britain rugby league player is one of three debutants, with centre Henry Slade and flanker Calum Clark the other new faces in the 15.
Head coach Lancaster says Saturday’s match is the final chance for some of his players to impress before he selects his 31-man World Cup squad.
“The following week we’ll probably change a lot,” he said
Burgess, 26, started his union career in midfield for Bath before switching to the back row.
Former England scrumhalf Matt Dawson has questioned Burgess’s “game-management” at inside centre, but Lancaster described the former South Sydney player, who switched codes last October, as a ball carrier who could threaten the gain line.
“It’s an option for us to look at and it’ll be an interesting insight to see whether it goes well at the weekend or not,” he said.
“It’s about what’s right for the team. We’ll see if he can translate what he does in training and see how it goes.”
Billy Twelvetrees has been handed his first start of the 2014 Internationals against Australia at Twickenham on Saturday with Owen Farrell reverting to the bench.
The Gloucester Rugby centre, who started every game in last season’s Six Nations campaign, takes the No 12 jersey and shifts Saracen Owen Farrell to the replacements’ bench as George Ford is retained at flyhalf.
Up front, Northampton Saints pair Tom Wood and Dylan Hartley take over from James Haskell (Wasps) and Rob Webber (Bath Rugby) at blindside flank and hooker respectively.
Despite those changes to the run-on side, the same match-day 23 who beat Samoa 28-9 last weekend will be on duty as England look to secure a 10th victory in 13 Twickenham Tests.
Reviewing his selection, Head Coach Stuart Lancaster praised Twelvetrees for his committed self-development over the current campaign.
Luther Burrell and Billy Twelvetrees are both in contention to face Samoa at Twickenham on Saturday, after Burrell was named in the group preparing for the third of England’s year-end Tests.
The Northampton Saints centre, who scored three tries in the 2014 Six Nations, is among 28 players recalled by Stuart Lancaster to Pennyhill Park on Monday – after recovering from a hand injury.
Bath wing Semesa Rokoduguni, missing from the 28-31 defeat to South Africa with a thigh injury, has not recovered sufficiently to retake his place in the squad and will remain at the club.
Domestic colleague Kyle Eastmond suffered concussion towards the end of the match last Saturday and will undergo the graduated return to play protocol in hope of playing against the South Sea Islanders.
Marlan Yarde will win his first England cap as Stuart Lancaster aim to secure a clean sweep against Argentina on Saturday. The 21 year-old London Irish flyer comes into the side on the left wing replacing David Strettle while Bath’s Kyle Eastmond will make his first Test start in the No.12 shirt vacated by Lions-bound Billy Twelvetrees.
Ireland wing Simon Zebo will make his British and Irish Lions debut against New South Wales Waratahs on Saturday. Zebo joined the squad as cover on Tuesday and goes straight into a strong side containing up to a dozen likely Test contenders.
England centre Billy Twelvetrees is joining the British and Irish Lions’ tour of Australia as cover for the tourists’ injury-affected backline. Twelvetrees, 24, has been on England duty in Argentina, scoring a try in the 32-3 win over the Pumas at the weekend.
Rob Webber will captain England for the first time in Sunday’s game against the Barbarians at Twickenham. The Bath hooker leads a youthful side which has nine players aged 24 or under in the starting XV and sees Matt Kvesic and Marland Yarde make their debuts.
Billy Twelvetrees has kept his place in England’s starting XV for Sunday’s match against Ireland in Dublin, while James Haskell makes his first start in the Six Nations since 2011.
Let’s start with the good news.
Scotland, a disorganised and calamity-prone shambles against Tonga in November, rejoined the international community with a display that was impressive in parts, effective in critical areas and well organised throughout.
And the bad news? They were up against England. New England. England on fire.
Gloucester centre Billy Twelvetrees will make his England debut in Saturday’s Six Nations match against Scotland at Twickenham. Twelvetrees, 24, replaces Manu Tuilagi and forms a midfield partnership with Brad Barritt of Saracens.
The only other change from the starting XV that beat New Zealand 38-21 in December is Joe Marler in for Alex Corbisiero at loose-head prop.
England coach Stuart Lancaster has included uncapped pair Calum Clark and Billy Twelvetrees in his 33-man squad for the Six Nations.
England have called Gloucester duo Freddie Burns and Billy Twelvetrees into their training squad ahead of the opening Autumn International against Fiji at Twickenham.