Rob Webber will captain England for the first time in Sunday’s game against the Barbarians at Twickenham. The Bath hooker leads a youthful side which has nine players aged 24 or under in the starting XV and sees Matt Kvesic and Marland Yarde make their debuts.
Six of the eight players on the bench could also make their first senior appearances in the non-cap game.
“This is a great opportunity for these players to step up,” said England head coach Stuart Lancaster.
England are without their British and Irish Lions contingent plus those from Leicester and Northampton, who contest the Aviva Premiership final on Saturday.
Webber, 26, has played just three game for England and will be joined in the front row by Bath team-mate David Wilson who is the most capped player in the side with 26 appearances.
London Irish prop Alex Corbisiero, Gloucester’s number eight Ben Morgan and Exeter’s Tom Johnson are all included after recovering from injury.
Freddie Burns, who had his Six Nations ambitions ended by injury, starts at fly-half with Richard Wigglesworth at scrum-half.
Billy Twelvetrees starts at inside centre alongside Jonathan Joseph and Mike Brown returns to his preferred position at full-back.
After playing the Barbarians England embark on a three-match tour, which starts in Uruguay against a combined South American XV and then head to Argentina for two Tests.
“Taking on a very experienced Barbarians team is the first challenge they face this summer with matches in Uruguay and Argentina to follow and this sequence of games is a key part of our development as a team,” continued Lancaster.
“Webber finished the season strongly with Bath and I know his leadership qualities well. I am sure he’ll show the way backed up by the other senior players in the team.”
England: Mike Brown; Christian Wade, Jonathan Joseph, Billy Twelvetrees, Marland Yarde; Freddie Burns, Richard Wigglesworth; Ben Morgan, Matt Kvesic, Tom Johnson; Dave Attwood, Joe Launchbury; David Wilson, Rob Webber, Alex Corbisiero
Replacements: David Paice, Joe Marler, Henry Thomas, Kearnan Myall, Billy Vunipola, Haydn Thomas, Jonny May, Kyle Eastmond
Meanwhile uncapped London Wasps back Elliot Daly has been named in the Barbarians starting line-up for the match. Daly, 20, missed out on an England place for June’s tour of Argentina.
James Hook will play at fly-half after failing to win a spot in the summer touring squads of either the British and Irish Lions or Wales.
Italy captain Sergio Parisse, who is currently at a training camp with his national team, will not be involved. The Stade Francais number eight, who led the Barbarians to wins over Wales and England in 2011, will be at the camp in Bormio until Saturday.
After the match at Twickenham, the Barbarians will fly to Hong Kong, where they will face the Lions on 1 June.
Sunday’s game is the latest chance to impress for Daly, an England Under-20 international who has also represented the Saxons side.
He scored seven tries in 30 appearances for Wasps as they finished the 2012-13 Premiership season in eighth place.
Daly is one of three uncapped players in the squad, with his Wasps team-mate and fellow England Under-20 international Sam Jones among the replacements.
Hook, who plays his club rugby for Perpignan, will make his Barbarians debut, having made three appearances as a replacement for Wales as they won the Six Nations earlier this year.
The 27-year-old failed to win a place in the Lions squad for the three-Test series against Australia, and was then left out of the Wales squad to tour Japan.
Wasps’ director of rugby Dai Young will lead a starting line-up that includes players from 11 countries, including Saracens’ South African hooker Schalk Brits and exciting United States wing Takudzwa Ngwenya.
Hong Kong sevens captain Rowan Varty will be among the replacements.
But there is no place for Ulster back Jared Payne, uncapped by New Zealand.
Barbarians: Elliot Daly (London Wasps); Timoci Nagusa (Montpellier, Fiji), Takudzwa Ngwenya (Biarritz, United States), Casey Laulala (Munster, New Zealand), Mike Tindall (Gloucester, England); James Hook (Perpignan, Wales), Dwayne Peel (Sale, Wales); Andrea Lo Cicero (Racing Metro 92, Italy), Matthew Rees (Scarlets, Wales), James Johnston (Harlequins, Samoa), Jim Hamilton (Gloucester, Scotland), Marco Wentzel (London Wasps, South Africa), Alessandro Zanni (Treviso, Italy), Imanol Harinordoquy (Biarritz, France), Jonathan Poff (London Wasps, New Zealand).
Replacements: Schalk Brits (Saracens, South Africa), Dean Mumm (Exeter, Australia), Duncan Jones (Ospreys, Wales), Sam Jones (London Wasps), Dimitri Yachvili (Biarritz, France), Nick Evans (Harlequins, New Zealand), Rowan Varty (DeA Tigers, Hong Kong).
Venue: Twickenham, London
Kick off: 1300 British Summer Time (1200 GMT, 1400 South African Time)